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Attacked the cipher, and nowadays even with sophisticated computer programs that try millions of possibilities in a matter of seconds. The idea for the encryption methods used came from Ed Scheidt, the former director of the CIA, who probably knew how to make things difficult. To increase the hardness of K4, Scheidt would probably think more like a cryptanalyst, trying to increase the complexity of the algorithm, the size of the key space, or perhaps the plaintext alphabet. An artist like Sanborn, on the other hand, might have a focus that is more visual than theoretical. So he changed something completely unexpected, something a cryptanalyst would never have thought of. Something that computers couldn't find because they can't "see" it.Go to Kryptos - The Cipher (Part 2)[1] Elonka Dunin, Slides - Def Con 12, Jul. 14 - Aug. 01, 2004[2] Craig Bauer, Gregory Link & Dante Molle, James Sanborn’s Kryptos and the matrix encryption conjecture, pages: 541-552, Cryptologica, published online: 27 Apr 2016[3]

IntroductionKRYPTOS - Von Jim Sanborn - Jim Sanborn, CC BY-SA 3.0, I think that KRYPTOS does not need any introduction, I will only give you a brief description of one of the most famous and only partially solved ciphers known today:KRYPTOS was constructed in Nov. 1990 on the ground of the CIA Headquarter in Langley, Virginia by Jim SanbornIt contains 4 ciphers (K1,K2,K3,K4) on its left side and some kind of Vigenère-Table on its right side.K1, K2 and K3 were solved by James Gillogly in 1999. Afterwards, the CIA and later the NSA claimed that they had a solution to the first three ciphers at an earlier point in time.Ed Scheidt, a cryptoanalyst and former director of the CIA, gave Sanborn the input of possible cryptographic techniques to use.K1 is a variant of the Vigenère-Cipher (Quagmire 3) with the codewords KRYPTOS and PALIMPSESTK2 is a variant of the Vigenère-Cipher (Quagmire 3) with the codewords KRYPTOS and ABSCISSAK3 is a Transposition cipherJim Sanborn said that the previous ciphers K1,K2 and K3 contain information that will help to solve the last cipher K42010 Sanborn published the clue that the 6 letters from 64-69 of the ciphertext K4 decrypt to 'BERLIN'. Four years later, he revealed that the characters 70-74 decrypt to 'CLOCK'However, K4 remains unsolved. This post is more of introductory nature, so if you already know a lot of KRYPTOS you will probably not learn anything new.Ciphertexts Below you find the ciphertext of the K1-K4 ciphers: Orange:K1, green:K2, blue:K3, yellow:K4$\small{\texttt{01| E M U F P H Z L R F A X Y U S D J K Z L D K R N S H G N F I V J}}$$\small{\texttt{02| Y Q T Q U X Q B Q V Y U V L L T R E V J Y Q T M K Y R D M F D}}$$\small{\texttt{03| V F P J U D E E H Z W E T Z Y V G W H K K Q E T G F Q J N C E}}$$\small{\texttt{04| G G W H K K ? D Q M C P F Q Z D Q M M I A G P F X H Q R L G}}$$\small{\texttt{05| T I M V M Z J A N Q L V K Q E D A G D V F R P J U N G E U N A}}$$\small{\texttt{06| Q Z G Z L E C G Y U X U E E N J T B J L B Q C R T B J D F H R R}}$$\small{\texttt{07| Y I Z E T K Z E M V D U F K

Lirentelimab met histologic co-primary endpoints but missed symptomatic co-primary endpoints in both ENIGMA and KRYPTOS studiesREDWOOD CITY, Calif., Dec. 21, 2021 (GLOBE NEWSWIRE) -- Allakos Inc. (the “Company” or “Allakos”) (Nasdaq: ALLK), a biotechnology company developing lirentelimab (AK002) for the treatment of eosinophil and mast cell-related diseases, today reported data from ENIGMA 2, a 24-week Phase 3 randomized, double-blind, placebo-controlled study of lirentelimab in patients with biopsy confirmed eosinophilic gastritis (EG) and/or eosinophilic duodenitis (EoD) and KRYPTOS, a 24-week Phase 2/3 randomized, double-blind, placebo-controlled study of lirentelimab in patients with biopsy-confirmed eosinophilic esophagitis (EoE). Both ENIGMA 2 and KRYPTOS studies met their histologic co-primary endpoints, but did not achieve statistical significance on the patient reported symptomatic co-primary endpoints.“We are deeply disappointed that the studies did not achieve their symptomatic endpoints,” said Robert Alexander, PhD, Chief Executive Officer of Allakos. “The company is grateful to the patients with eosinophilic gastrointestinal diseases (EGIDs) and to the investigators who participated in the ENIGMA and KRYPTOS trials.”Dr. Craig Paterson, MD, Chief Medical Officer of Allakos added, “Although the EGID results are surprising and disappointing, we will continue to analyze the data to understand the results and to determine the path forward for lirentelimab in EGIDs. At present we intend to continue our development efforts with subcutaneous lirentelimab in atopic dermatitis, chronic spontaneous urticaria, and asthma. The atopic dermatitis study is underway and we plan to initiate chronic spontaneous urticaria and asthma studies in 2022 and will continue to advance other programs in our preclinical pipeline.”ENIGMA 2 Phase 3 Topline ResultsThe co-primary endpoints for the Phase 3 study were (1) the proportion of patients achieving histologic resolution (defined as ≤4 eosinophils (eos) / high powered field (hpf) in 5 hpfs in the stomach and/or ≤15 eos/hpf in 3 hpfs in the duodenum) and (2) symptomatic improvement as measured by absolute change in the six symptom total symptom score (TSS). Co-Primary Endpoints Lirentelimab (n=91) Placebo (n=89) Histology Endpoint: Proportion of responders as determined by gastric or duodenal tissue eosinophil counts1 84.6%(p 4.5% Symptom Endpoint: Absolute mean change in patient reported Total Symptom Score (TSS-6)2 Baseline TSS: 29.5 Baseline TSS: 27.7 -10.0 (p=0.343) -11.5 1 = A responder is a patient achieving the following peak eosinophil counts: eosinophil count ≤4 cells per hpf in 5 gastric hpf and/or eosinophil count ≤15 cells per hpf in 3 duodenal hpf. Endpoint assessed at end of Week 24.2 = TSS-6 is daily patient reported symptom questionnaire assessing 6 symptoms (abdominal pain, nausea, bloating, early satiety, abdominal cramping, and loss of appetite) on a scale from 0 to 10. Endpoint assessed as mean change from baseline to Weeks 23-24.The safety results of the trial were generally consistent with previously reported lirentelimab studies. No new safety signals were observed. Mild to moderate infusion-related reactions (including flushing, feeling of warmth, headache, nausea, and/or dizziness) occurred in 34% of lirentelimab-treated patients and 14% of placebo-treated patients.KRYPTOS Phase 2/3 Topline ResultsThe co-primary endpoints for the Phase 2/3 study were (1) the proportion of patients achieving

Thorns in the flanks of the leviathan that distract it from the swordthrust to the vitals.At Cavor Sarta, an Iron Hand known as Sabak Wayland and the lone Raven Guard survivor Nykona Sharrowkyn had captured an Unlingual Cipher Host -- one of the so-called "Kryptos" -- a hybrid abomination creature of the Dark Mechanicum that had previously made the Traitors' code network a cryptographic impossibility to break. With the Kryptos, Loyalist commanders were able to finally access the Traitors' coded communications.And with this knowledge, the Sisypheum 's Captain, the Iron Hand Ulrach Branthan, had ordered the Sisypheum to make the circuitous journey to Hydra Cordatus and the meeting of the Traitor Primarchs that had been indicated by the cracked communications. After learning of Fulgrim's intentions to enter the Eye of Terror and recover the Angel Exterminatus, the crew of the Sisypheum made their way towards the Warp Rift, aided by a mysterious Eldar guide with the intention of thwarting the Traitors' plan to acquire the unknown xenos weapon.Crone WorldThe destination of the joint fleet of Iron Warriors and Emperor's Children vessels was the lost Aeldari world of Iydris, a world said to have been favoured by the goddess Lileath. Iydris was one of the legendary Crone Worlds, which once formed the heart of the ancient Aeldari Empire before they were consumed by the creation of the vast Warp rift that was the Eye of Terror following the birth of the Chaos God Slaanesh.The Crone World was located at the heart of the Eye of Terror, somehow remaining in a fixed position keeping it from destruction in the gravitational hellstorm of a supermassive black hole that lay at the centre of the eternal Warp Storm. It was from this epicentre that the galaxy vomited unnatural matter into the void, a dark